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Plain English Summary. Background and study aims. Prostate cancer is a leading cause of cancer death among men in the Western world. A PSA test looks for raised levels of PSA in the blood that may be a sign of prostate cancer in its early stages. Although PSA screening has been shown to prevent deaths, it can also
STHLM3. Prostate-specific antigen (PSA) is used to test for prostate cancer but is considered to have a high false-positive rate that translates into unnecessary prostate biopsies and over- diagnosis of low-risk prostate cancers. The STHLM3 study aimed to develop a model for prostate cancer screening with better test
22 Mar 2016 As previously reported by Medscape Medical News, the prospective STHLM3 study published last year (Lancet Oncol. 2015;16:1667-1676) showed that the STHLM3 algorithm performed significantly better than PSA alone for the detection of cancers with a Gleason score of at least 7 (P < .0001).
For example, The Stockholm 3 (STHLM3) study utilized a blood test to obtain plasma protein biomarkers (PSA, free PSA, intact PSA, hK2, MSMB, MIC1), and genetic polymorphisms (232 SNPs). These results were added to patient clinical factors (age, family history, previous negative prostate biopsy, prostate exam) and
Test may diagnose prostate cancer more accurately. Published: March, 2016. A study in the December 2015 issue of The Lancet Oncology found that a new test, called STHLM3, is more helpful at detecting aggressive cancer than traditional tests for prostate-specific antigen (PSA). The STHLM3 test is a blood test that
17 May 2016 The DNA profiling aspects of the Pyramid Model involve two main strategies: (1) the analysis of germline (inherited) DNA early in adulthood targeting disease-specific, risk-associated single nucleotide polymorphisms (SNPs) and high penetrance mutations (HPMs) to guide targeted screening, prevention,
medicine using cancer screening as a case study. Ola Spjuth,1,2 Andreas Karlsson,1 Mark Clements,1 . (node 3 of the figure). This guides the choice of data sources and the first-stage analytic approach. . STHLM3 study followed a paired screen positive design, where 2 tests (PSA alone and S3M) were performed on
24 Nov 2015 In their new study, Gronberg and colleagues investigated whether the Stockholm 3 (STHLM3) model (which combines serum PSA level, levels of other plasma protein biomarkers, SNPs and clinical variables such as age and family history) could improve the specificity of detection of high-risk prostate
23 Nov 2016 Table 1Baseline characteristics of men included in the Current Prostate Cancer Testing cohort (Stockholm, 2011) and Stockholm-3 model (STHLM3) study cohort (Stockholm, 2012–2014)
28 Mar 2017 Detection of Prostate Cancer Using a Multistep Approach with Prostate-specific Antigen, the Stockholm 3 Test, and Targeted Biopsies: The STHLM3 MRI The aim of the STHLM3 magnetic resonance imaging (MRI) study is to provide evidence of an improved and structured multistep pipeline for prostate

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February 2018