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dna lesion

hydroxylating agents definition

pyrimidine dimers

nucleotide excision repair

dna adduct definition

how do dna adducts cause cancer

dna adduct repair

types of dna adducts

In molecular genetics, a DNA adduct is a segment of DNA bound to a cancer-causing chemical. This process could be the start of a cancerous cell, or carcinogenesis. DNA adducts in scientific experiments are used as biomarkers of exposure and as such are themselves measured to reflect quantitatively, for comparison, the
Gene-specific Formation and Repair of Cisplatin Intrastrand Adducts and Interstrand Cross-links in Chinese Hamster Ovary Cells*. (Received for publication, August 15, 1990). Jennifer C. Jones, Weiping Zhen, Eddie Reed$, Ricardo J. Parker$, Aziz Sancarg, and. Vilhelm A. Bohrll. From the Laboratory of Molecular
adducts (15). An alternative methodology employing the polymerase chain reaction has recently been reported (15-17). This approach has exploited the loss of template activity of a target gene due to . according to the manufacturer's instructions. .. Results for bulk DNA repair deficiency in GM4429 cells and replication.
5 Sep 2010 There are multiple repair pathways responsible for protecting against the genotoxic effects of these adducts, including adduct reversal as well as base and nucleotide excision repair pathways. Data indicate that several DNA adducts contribute to the overall mutagenic properties of pyridyloxobutylating
Here, we describe the structural and biochemical properties of YTM adducts that are responsible for their toxicity, and define the mechanism by which they are excised by AlkD. These findings delineate an alternative strategy for repair of bulky DNA damage and establish the cellular utility of this pathway relative to that of
Large bulky adducts are produced or formed from many of the large organic carcinogenic compounds, including PAHs, aromatic amines, and aflatoxin. in the carcinogenesis process is dependent in part on the persistence of the adduct through cell proliferation, which is also in part dependent upon DNA repair (Swenberg
11 Oct 1996 Somatic cells obtained from these patients are also defective in excision repair of bulky DNA adducts resulting from genotoxic chemicals (1, 2, 4). Recent in vitro studies using cell-free extracts showed that the range of base lesions processed by mammalian NER extends to nonbulky adducts, and even
17 Sep 2010 The analysis of formation and repair of smoking-related DNA adducts remains particularly challenging as both smokers and nonsmokers exposed to smoke are repetitively under attack from complex mixtures of carcinogens such as polycyclic aromatic hydrocarbons and N-nitrosamines. The bulky DNA
5 DNA Adducts and. Their Consequences. Frederick A. Beland. National Centerfor ToxicologicalResearch, Jefferson, Arkansas USA. Miriam C. Poirier. National suggesting that these adducts are subject to enzymatic repair processes. . associated DNA as compared with bulk chromatin in livers from rats administered.
8 Jul 2010 Formation, Repair, and Genotoxic Properties of Bulky DNA Adducts Formed from Tobacco-Specific Nitrosamines. Lisa A. Peterson D. Hoffmann and S. Hecht, “Advances in tobacco carcinogenesis," in Handbook of Experimental Pharmacology, C. S. Cooper and P. L. Grover, Eds., pp. 63–102, Springer

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