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28 Mar 2017 We analyze ex-vivo-cultured primary cells using phosphoproteomics d. We investigate epithelial ovarian cancer (EOC) and healthy tissue d. We uncover expression of cancer-specific proteins and kinase signatures d. The kinase CDK7 phosphorylates POLR2A and regulates. EOC cell proliferation. Authors.
14 Mar 2017 Resource. Integrative Proteomics and Phosphoproteomics. Profiling Reveals Dynamic Signaling Networks and. Bioenergetics Pathways Underlying T Cell Activation. Graphical Abstract. Highlights d. Proteome and phosphoproteome profiling reveals temporal dynamics of T cell activation d. TCR activates
REVIEW. Analytical strategies for phosphoproteomics. Tine E. Thingholm1, 2, Ole N. Jensen2 and Martin R. Larsen2. 1 KMEB, Department of Endocrinology, Odense University Hospital, Odense M, Denmark. 2 Department of Biochemistry and Molecular Biology, University of Southern Denmark,. Odense M, Denmark.
biological interpretation of phosphorylation events are discussed. KEYWORDS: bioinformatics analyses • mass spectrometry • phospho-enrichment strategies • phosphoproteomics. • quantitative phosphoproteomics. Current status & future challenges in the phosphoproteomics field. Site-specific protein phosphorylation is a.
15 Dec 2017 Summary. Phosphorylation is regarded as one of the most prevalent post-translational modifications and plays a key role in regulating cellular processes. In this work we carried out a comparative bioinformatics analysis of phosphoproteomics data, to profile two model species representing the largest
of phosphoproteomics research. The human kinome consists of 518 protein kinases, compared with. 228 in fruit flies and 130 in yeast (Table 1). The expansion of the protein kinase families in higher metazoans accounts for the observed cellular and functional diversity between these organisms. Most of the unique families
20 Dec 2017 Full-text (PDF) | In recent years, thanks to advances in Mass Spectrometry (MS)-based quantitative proteomics, studies on signaling pathways have moved from a detailed description of individual components to system-wide analysis of entire signaling cascades, also providing spatio-temporal views of
22 Dec 2017 Request (PDF) | Quantitative phospho | Protein phosphorylation is the most important type of reversible post-translational modification involved in the regulation of cellular signal-transduction processes. In addition to controlling normal cellular physiology on the molecular level, perturbations of
3 Oct 2008 Phosphoproteomics: Principles and Applications. Boris Macek, Matthias Mann, and Jesper V. Olsen. Max Planck Institute for Biochemistry, Martinsried, Germany; email: olsen@biochem.mpg.de. Annu. Rev. Pharmacol. Toxicol. 2009. 49:199–221. First published online as a Review in Advance on. October 3
Protein phosphorylation is the best-studied posttranslational modification and plays a role in virtually every biological process. Phosphoproteomics is the analysis of protein phosphorylation on a proteome-wide scale, and mainly uses the same instrumentation and analogous strategies as conventional mass spectrometry.

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February 2018