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Schematic....structure....of....an....antibody-drug....conjugate....(ADC)....(link)...^...Zawada,...JF;...Yin,...G;...Steiner,...AR;...Yang,...J;...Naresh,...A;...Roy,...SM;...Gold,...DS;...Heinsohn,...HG;...Murray,...CJAntibody-drug..conjugates..or..ADCs..are..an..important..class..of..highly..potent..biopharmaceutical..drugs..designed..as..a..targeted..therapy..for..the..treatment..of..people..with..cancer.[1][2][3][4][5][6][7]..Unlike..chemotherapy,..ADCs..are..intended..to..target..and..kill..only..the..cancer..cells..and..spare..healthy..cellsGThe...type...of...linker,...cleavable...or...noncleavable,...lends...specific...properties...to...the...cytotoxic...(anti-cancer)...drugdoi:10.1182/blood-2003-07-2466
This..unsaturated..imide..is..an..important..building..block..in..organic..synthesisReferences[edit]Maleimide....is....a....chemical....compound....with....the....formula....H2C2(CO)2NH....(see....diagram)^...Sastia...Pdoi:10.1021/np9002806...^...Koniev,...O.;...Wagner,...AThe..double..bond..readily..reacts..with..all..hydroxy,..amine..or..thiol..groups..found..on..the..matrix..to..form..a..stable..carbon-oxygen,..carbon-nitrogen,..or..carbon-sulfur..bond,..respectively"Studies....on....the....biochemistry....of....microorganismsM.;...Ritland,...M.;...Hutchins,...BFood..and..Drug..Administration..(FDA)..on..August..19,..2011..for..relapsed..HL..and..relapsed..sALCL..and..conditional..Marketing..authorization..from..the..European..Medicines..Agency..in..October..2012..for..relapsed..or..refractory..HL..and..relapsed..or..refractory..sALCL
^...a...b...Axup,...JY;...Bajjuri,...KM;...Ritland,...M;...et...al^..Chari,..Ravi..V"Antibody-Drug..Conjugates..Designed..to..Eradicate..Tumors..with..Homogeneous..and..Heterogeneous..Expression..of..the..Target..Antigen"PMID2133733752....(1):....12731PMID19769391doi:10.1038/nrd.2016.268"Cell...killing...by...antibody-drug...conjugates" 985d112f2e
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