ng0703-244. PGC-1 alpha at the crossroads of type 2 diabetes. Alan D Attie & Christina M Kendziorski. A.D.A. is in the Department of Biochemistry and C.M.K. is in the Department of Biostatistics and Medical Informatics at the University of
References•; Author information. Garrod, A.E. Lancet ii, 1616–1620 (1902). Article. Garrod, A.E. Inborn Factors in Disease (Oxford University Press, Oxford, 1931). Illig, T. et al. Nat. Genet. 42, 137–141 (2010). ChemPort · PubMed · Article. Kathiresan, S. et al. Nat. Genet. 41, 56–65 (2009). ChemPort · PubMed · Article.
1 Jul 2004 Mootha et al. propose a statistical method (Gene Set Enrichment Analysis; GSEA) to discern changes in expression levels of sets of genes selected a priori in transcriptional profiling experiments. Although consideration of groups of genes is an interesting strategy, the proposed test statistic may not
By combining this expanded inventory with genetic intervals linked to disease, we have identified candidate genes for eight mitochondrial disorders, leading to the .. Mootha, V.K. et al. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria . Cell 115, 629–640 (2003).
1 Jan 2004 They identified 399 mitochondrial proteins using liquid chromatography tandem mass spectrometry. Of these proteins, 75 were new and 88 had recently been identified as mitochondrial proteins. Although some could be contaminants, most seem authentic based on multiple lines of evidence. Mootha et al.
Here we detail a hybrid procedure to map loci involved in complex traits that leverages the strengths of forward and reverse genetic approaches. By integrating Mootha, V.K. et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes . Nat. Genet.

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March 2018