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5 Jan 2016 mors (NET) G1/G2. According to the WHO classification of 2010, NEC are defined as poorly differentiated NEN with Ki-67 >20% and hence G3. Increasing evidence suggests High-Grade GEP Neuroendocrine. Tumors and NEC NEC is by definition G3, either based on a proliferation index >20% or >20
Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. Many are benign, while some are malignant. They most commonly occur in the intestine, where they are often called carcinoid tumors, but they are also found in the pancreas, lung and the rest of the body.
The ESMO Clinical Practice Guidelines (CPG) are intended to provide the user with a set of recommendations for the best standards of cancer care, based on the findings of evidence-based medicine.
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5 Jan 2016 This guideline encompasses all WHO grade 3 gastroenteropancreatic (GEP) neoplasms; however, in the future grade 3 neuroendocrine neoplasms will probably be separated according to differentiation, as explained below and potentially according to organ of origin such as for well differentiated NET
In recent years, it was felt that WHO classification should be supplemented by criteria that may refine the prognostic stratification of GEP-NETs to allow a better stage-adjusted treatment. Therefore, European Neuroendocrine Tumor Society (ENETS) developed TNM classifications [12,13]. Meanwhile, the definition of the
J Clin Oncol. 2017;35(suppl 4S). 27. Jalbert JJ, Casciano R, Tao B, et al. Treatment patterns among patients with metastatic GEP-NET treated at a tertiary referral center [ASCO GI abstract 397]. J Clin Oncol. 2017;35(suppl 4S). 28. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Neuroendocrine tumors.
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