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26 Feb 2016 [15] In contrast to anthracycline-induced cardiotoxicity, trastuzumab exposure can result in LVD and HF that appears mostly reversible.[45] At highest risk for cardiotoxicity from trastuzumab exposure are those aged >50 years, patients with underlying heart disease or hypertension, those with baseline LVEF
1 May 2002 Cardiac contractile dysfunction is the most serious cardiotoxic effect of anthracycline therapy and a major limitation for the use of this effective antineoplastic treatment. The reported incidence of doxorubicin-induced cardiac dysfunction varies from 4%, at a cumulative dose of 500–550 mg/m2, to >36% in
20 Dec 2016 The mechanism, clinical manifestations, monitoring, and diagnosis of anthracycline-induced cardiotoxicity and cardiovascular complications of other classes Although guidelines have not included baseline electrocardiogram in their recommendations, some UpToDate contributors find it helpful to obtain a
4 Jun 2012 Anthracycline-induced cardiotoxicity in long-term survivors of childhood cancer is characterised by reduced left ventricular wall thickness and mass, Its long-term benefits remain to be determined, and data remain insufficient to make specific recommendations regarding current use of dexrazoxane (9).
20 Jul 2017 The very effective anticancer drug doxorubicin (DOX) is known to have cardiotoxic side effects, which could be accompanied by autonomic modulation. Autonomic disbalance might even be an initiating mechanism underlying DOX-induced cardiotoxicity and can be studied noninvasively by the analysis of
While anthracycline-induced cardiomyopathy was found to be rarely and never fully reversible when recognized and treated late, resolution can be noted with close .. Management of patients who sustain cardiotoxicity during or after cancer therapy should be in keeping with the AHA/ACC heart failure guidelines.
9 Feb 2017 The exact mechanism of anthracycline-induced cardiotoxicity remains unclear, though it is likely to be multifactorial. Authors/task force members; ESC Committee for Practice Guidelines (CPG): ESC position paper on cancer treatments and cardiovascular toxicity developed under the auspices of the
17 Feb 2016 for cancer therapy-induced cardiotoxicity. These toxicities, which might include left ventricular (LV) dysfunction, hy- pertension, myocardial ischemia, arterial thrombosis, and ar- rhythmias are discussed in greater detail in the following sections. LV dysfunction. Risk factors for anthracycline-induced heart.
28 Nov 2016 Cancer therapy–induced cardiomyopathy has gained increasing importance with the remarkable improvement in overall cancer survival during the past .. in patients with anthracycline-related cardiomyopathy, supporting recommendations for cardiac function monitoring in exposed cancer survivors (35).
term cardiac effects of anthracycline chemotherapy are available. Actually, the incidence and the timing of occurrence of anthracycline-induced cardiotoxicity are, as yet, not well defined. Risk factors for anthracycline toxicity include cumulative dose, intravenous bolus administration; higher single doses; history of prior
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