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Catalog No. Form. Amount. Excitation. Peak Emission. A14890. PE-Cy®7. 25 µg. 488 nm. 767 nm. Product Description. The Rat anti-Mouse CD45 Monoclonal Antibody (mAb) recognizes all isoforms of the CD45 antigen, a transmembrane tyrosine Read the. Safety Data Sheets (SDSs) and follow the handling instructions.
190, 2 @ 205, and 220 kDa) of the CD45 family, also called the leucocyte common antigen family (LCA family). At the Fourth International Workshop on Human Leucocyte. Differentiation Antigens (Vienna 1989) the CD45 family was further divided into four groups of non-restricted and restricted isoforms (CD45R): CD45,
The CD45 antibody recognizes the human CD45 antigen, a tyrosine phosphatase also known as leukocyte common antigen (LCA). The CD45 molecule is required for T and B cell activation and is expressed in at least five isoforms depending on the differentiation status of the cell. The CD45 antibody recognizes a common
Protein tyrosine phosphatase, receptor type, C also known as PTPRC is an enzyme that, in humans, is encoded by the PTPRC gene. PTPRC is also known as CD45 antigen which was originally called leukocyte common antigen (LCA). Contents. [hide]. 1 Function; 2 Isoforms; 3 Interactions; 4 Clinical importance; 5 Use as a
CD45 antigen characterization, plus the various isoforms of CD45 discussed along with their structure and function, antibodies available to these isoforms identified. by antibody affinity chromatography. In Handbook of Experimental Immunology, Weir DM and Herzenberg LA ed. (Blackwell Scientific Publications; Oxford,
15 Mar 2006 Thus, for the first time, we have shown experimentally that it is the combination of CD45 isoforms that affects immune function and disease. . were analyzed on a FACSCalibur (BD Biosciences), using CellQuest and BD cytometric bead array software, in accordance with the manufacturer's instructions.
The CD45 isoforms detected in the mouse are cell type-, maturation-, and activation state-specific. The CD45 isoforms play complex roles in. T-cell and B-cell antigen receptor signal transduction. The 104 antibody has been reported to inhibit some responses of B cells, from mice expressing the CD45.2 alloantigen,
CD45 antigen is found on all leukocytes and cells of hematopoietic origin, but not erythrocytes. The YW62.3. mAb recognizes all isoforms of CD45 antigen and can be used in immunostaining for flow cytometry. PRODUCT QUALITY CONTROL. Every lot is tested by flow cytometry using freshly harvested mouse splenocytes.
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