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Microencapsulation: Methods And Industrial Applications (Drugs And The Pharmaceutical Sciences) Down ->>->>->> http://shorl.com/frynetutydisti
A study by Hasan et alThis, in turn, has improved the therapeutic efficacy of the molecule with advantages of low dosage requirements and with the ability to be delivered at the targeted site without enzyme degradation by biological fluid proteinsEarly research in the field of microencapsulated microorganisms was undertaken, by Prakash and Chang, using a genetically modified Escherichia coli strain (DH5) containing a urease gene from Klebsiella aerogenes [2, 126]In recent years, the microencapsulation of probiotic cells, “live microorganisms, which, when administered in adequate amounts, confer a health benefit on the host," has gained interest for the treatment of a number of gastrointestinal and other health disorders [125]The delivery of mammalian cells has been proposed to promote the regeneration of organs such as the liver, pancreas, heart, and kidneyMost of the commonly used polymers for drug applications are poly (lactic acid) (PLA) and poly (lactic-co-glycolic acid) (PLGA) [90, 150]
Babtsov et al., demonstrated microencapsulation of protein loaded chitosan nanoparticles by spray drying for pulmonary delivery of drugs [160]Administration of the probiotic led to a significant reduction in the number of adenomas and gastrointestinal neoplasias in the treated animals, suggesting that the microencapsulated bacteria could have a role in the development of a successful colon cancer therapeuticinvestigated APA microencapsulated genetically modified bile-salt-hydrolase (BSH-) active Lactobacillus plantarum 80 (pCBH1) for its capability to break down and remove bile acids [10]It could be through conference attendance, group discussion or directed reading to name just a few examplesThere are a number of techniques that can be used to fabricate microcapsules, depending on the desired characteristics and applications of the final microcapsule formulationMicrocapsules, containing 1-2 NPCCs, were manufactured using highly purified alginate cross-linked by barium chloride [26]This mixture is then heated to evaporate the solvent, followed by temperature reduction
There are a number of already marketed microencapsulated products for the delivery of pharmaceutics [1]The encapsulation was performed by gelation of alginate in calcium chloride, followed by coating steps with polylysine and alginate, to give rise to alginate-polylysine-alginate (APA) microcapsules containing Efermentum for the treatment and prevention of metabolic syndrome [15]Other polysaccharides such as chitosan [80, 151, 152], alginate [153], and lipids [70, 154, 155] have also been exploredFurther research investigated the ability of APA microencapsulated LThe title will be removed from your cart because it is not available in this regionRat hepatocytes, encased in APA microcapsules, were shown to secrete urea and albumin in vitro, two molecules secreted by the normal healthy liverIn addition to the presented applications, other applications are also promising [173–175]A recent study performed by Teng et alIt was demonstrated that, following gastrointestinal exposure, there was a significant 2.5 log difference in viability between the free and microencapsulated L
also investigated the use of APA microencapsulated bacteria, specifically feruloyl esterase (FAE) active Lfermentum cells [14]Acknowledgmentsevaluated the function of PIC APA microcapsules in a single type 1 diabetic patient [29]The process of microencapsulation can be used in designing therapeutic formulations of microbial cells, mammalian cells, drugs, and other molecular pharmaceutics 5c5c846363
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