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3 Dec 2015 Guidelines for use of HIGH DOSE METHOTREXATE (HDMTX): Glucarpidase is an orphan medicine and is not licensed in the UK, therefore
2 Aug 2010 Presence of grade 4 toxicity before administration of glucarpidase, .. Optimal management of methotrexate intoxication in a child with
22 Nov 2012 Glucarpidase is a recombinant form of carboxypeptidase G2, Sultan I. Low-dose carboxypeptidase-G2 for methotrexate toxicity in a child.
VORAXAZE® (glucarpidase) VORAXAZE® (glucarpidase) is a carboxypeptidase enzyme indicated . Criteria for Adverse Events" (CTCAE) version 3 scale.
creased hydration, high-dose leucovorin, and glucarpidase are . Glucarpidase eliminates extracellular MTX and levetiracetam in a child treated for acute.
14 Jul 2016 2Department of Child Oncology, University Medical Centre, Groningen, Methotrexate; Glucarpidase; Voraxaze; Child; Intoxication; Toxicity.
In addition, the use of glucarpidase (Voraxaze) may be considered, which is an enzyme capable of Accidental methotrexate ingestion in a 19-month-old child.
The FDA-approved glucarpidase in 2012 as an antidote to methotrexate toxicity secondary See VA PBM-MAP and Center for Medication Safety's Guidance on
NHS England will commission Glucarpidase for the urgent treatment of methotrexate-induced renal dysfunction in accordance with the criteria outlined in .. when a child has: raised Methotrexate levels at specified time points post high dose.
The manufacturer recommends caution if the drug is administered to a woman who is breast-feeding a child because many drugs are excreted in human milk.

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March 2018