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Although drugs are a common cause of acute immune-mediated thrombocytopenia in adults, the drug etiology is often initially unrecognized. Most cases of drug-induced thrombocytopenia (DITP) are caused by drug-dependent antibodies that are specific for the drug structure and bind tightly to platelets by their Fab regions
15 Mar 2012 Patients with isolated thrombocytopenia commonly have drug-induced thrombocytopenia, immune thrombocytopenic purpura, pseudothrombocytopenia, or if pregnant, gestational thrombocytopenia. A history, physical examination, and laboratory studies can differentiate patients who require immediate
Drug-induced thrombocytopenia was first described in the 19th century, yet our understanding of its pathogenesis continues to evolve. The list of drugs implicated in drug- induced thrombocytopenia is extensive and growing. Many, if not most, of these medications induce thrombo- cytopenia by immune mechanisms.
8 Jul 2013 Drug-induced immune thrombocytopenia (DITP) is a challenging clinical problem that is under-recognized, difficult to diagnose and associated with .. Accessible and reliable laboratory testing would help establish the diagnosis of DITP and provide guidance for clinicians and patients on the need for drug
4 Nov 2017 The goal of medical care for immune thrombocytopenic purpura (ITP) is to increase the platelet count to a safe level, permitting patients to live normal lives while awaiting spontaneous or treatment-induced remission. ITP has no cure, and relapses may occur years after seemingly successful medical or
26 Apr 2017 This topic review discusses drug-induced immune thrombocytopenia (DITP), in which the mechanism involves antibody-mediated platelet destruction caused by exposure to a drug that leads to isolated thrombocytopenia (without anemia or leukopenia). Neonates – (See "Causes of neonatal thrombocytopenia".)
16 Jun 2017 Drug-induced thrombocytopenia occurs when certain medicines destroy platelets or interfere with the body's ability to make enough of them. There are two types of drug-induced thrombocytopenia: immune and nonimmune. If a medicine causes your body to produce antibodies, which seek and destroy your
AFLP (acute fatty liver of pregnancy). Table 1. Causes and Relative Incidence of Thrombocytopenia in Pregnancy. Pregnancy-specific. Not pregnancy-specific. Isolated throm- bocytopenia. Gestational thrombocy- topenia (70-80%). Primary ITP (1-4%). Secondary ITP (<1%)*. Drug-induced thrombocytopenia **. Type IIB von
Immune-mediated platelet consumption is associated with a large number of drugs leading to drug-induced immunologic thrombocytopenia (DITP) in which platelet destruction is caused by immunoglobulins that recognize specific platelet membrane glycoproteins (GPs) only in the presence of the sensitizing drug noncovalently
We present a rare complication of the use of imatinib that caused drug-induced immune thrombocytopenia (DIT) in a patient with a gastrointestinal stromal tumour . R. McMillan, J.A. Okerbloom, D.H. Regan, I. WarrierIdiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American

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February 2018