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$Guide it trial jama: >> http://skc.cloudz.pw/download?file=guide+it+trial+jama << (Download) Guide it trial jama: >> http://skc.cloudz.pw/read?file=guide+it+trial+jama << (Read Online) 20 Sep 2017 The American College of Cardiology/American Heart Association HF guideline (NEJM JW Cardiol Sep 2017 and Circulation 2017; 136:e137) supports the use of these biomarkers for diagnosis and prognosis but not for directing therapy. To learn more, researchers in the GUIDE-IT trial enrolled 894 patients 22 Aug 2017 2017;doi:10.1001/jama.2017.10540 “Perhaps the most likely explanation for the outcomes observed in the GUIDE-IT trial is that when clinical care follows guidelines and addresses the key issues, biomarkers do not make a difference and that guideline-directed care, if achieved, is more efficient and can However, results from individual trials have not been uniform. Moreover, the large GUIDE-IT (Guiding Evidence-Based Therapy Using Biomarker Intensified Treatment) study investigating NT-proBNP–guided therapy was stopped early by the Data Safety Monitoring Board owing to lack of difference between the 2 groups. 22 Aug 2017 Comment in JAMA. 2017 Aug 22;318(8):707-708. J Thorac Dis. 2017 Nov;9(11):4137-4140. Importance: The natriuretic peptides are biochemical The Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure (GUIDE-IT) study was a randomized multicenter clinical trial 24 Aug 2017 JAMA 2017;318:713-720. The GUIDE-IT (Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure) study was a randomized multicenter clinical trial conducted Hopefully, a post-hoc analysis of this important study will allow better design of future clinical trials of acute HF. Usual Care group will receive standard heart failure treatment based on the doctor's best judgment and following the recommendation of current guidelines. . Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial. JAMA. 2017 Aug 22;318(8):713-720. doi: 10.1001/jama.2017.10565. 22 Aug 2017 Design, Settings, and Participants The Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure (GUIDE-IT) study was a randomized multicenter clinical trial conducted between January 16, 2013, and September 20, 2016, at 45 clinical sites in the United States and Canada. 22 Aug 2017 No difference in the proportion of GUIDE-IT trial patients who hit target biomarker level. peptide-guided therapy on hospitalization or cardiovascular mortality in high-risk patients with heart failure and reduced ejection fraction: a randomized clinical trial" JAMA 2017; DOI: 10.1001/jama.2017.10565. Results from smaller prospective, randomized studies of this strategy thus far have been mixed, and current guidelines do not recommend serial measurement of NP levels to guide therapy in patients with HF. METHODS GUIDE-IT is a prospective, randomized, controlled, unblinded, multicenter clinical trial designed to.$