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20 Nov 2017 A recent abstract presented at the American Society of Clinical Oncology (ASCO) annual meeting compared 2 risk models for patients with intermediate chemotherapy-induced neutropenia (CIN) risk and compared them to guidelines from ASCO and the National Comprehensive Cancer Network to
Neutropenia and its complications may also lead to chemotherapy dose reductions, treatment delays, or early treatment termination, compromising disease control and the potential for cure. NCCN Clinical Practice Guidelines in Oncology recommend administration of primary prophylaxis with a myeloid growth factor in
Society for Medical Oncology (ESMO) guidelines, growth factor support may be used in acute myeloid leukemia (AML) trials not to reduce infections but to increase efficacy of chemotherapy [32]. growth factors; secondary prophylaxis. Patients with neutropenic fever have an increased risk to develop the same problem
based on the type of cancer, chemotherapy regimen, patient-specific risk factors and treatment intention, a formal risk assessment is encouraged (see Figure 5). Like the EORTC guidelines, the NCCN guidelines recommend the use of G-CSF prophylaxis in cancer patients at 20% or greater risk of febrile neutropenia.
29 Sep 2015 Chemotherapy-induced neutropenia is a known source of major stress for physicians and patients. Febrile neutropenia is a serious clinical problem 1–5. In many cases, G-CSFs are administered to patients with malignancy to prevent such events. International guidelines for the use of G-CSF include the
Background: The National Comprehensive Cancer Network (NCCN) and the American Society of Clinical Oncology (ASCO) have published guidelines for use of prophylactic colony stimulating factors (CSF) for patients at risk for chemotherapy induced neutropenia (CIN).
Management of chemotherapy-induced neutropenia: measuring quality, cost, and value. NCCN Clinical Practice Guidelines in Oncology recommend administration of primary prophylaxis with a myeloid growth factor in patients receiving regimens associated with a high risk for febrile neutropenia, and consideration of
The National Comprehensive Cancer Network has published guidelines on the use of myeloid growth factors. Patients who are at high risk of neutropenia (>20% risk of developing febrile neutropenia) prior to the start of their treatment regimen or who are receiving a chemotherapy regimen that is associated with a high risk
All of the guidelines focus on people whose risk is at least 20%, so if the physician thinks that the patient has a 20% or greater risk of developing febrile neutropenia at some point during their clinical course with whatever chemotherapy regimen is planned, they should get first-cycle prophylaxis with a G-CSF agent.
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