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Anaesthesia. 2009 Sep;64(9):990-1003. doi: 10.1111/j.1365-2044.2009.05986.x. Hypertonic saline in critical care: a review of the literature and guidelines for use in hypotensive states and raised intracranial pressure. Strandvik GF(1). Author information: (1)Anaesthesia and Intensive Care Medicine, South Eastern School
30 May 2006 NEUROICU Guideline: Osmotherapy for Treatment of Intracranial Hypertension. Hypertonic Saline- 3% NaCl. Goal: To maintain therapeutic serum osmolality in severely brain-injured patients refractory to. 5%NaCl. Patient Eligibility: 1. Patient must be in the NeuroICU and administration of therapy must be
4. The initial rate of hypertonic saline administration is not to exceed 50 ml per hour. Serum sodium and serum osmolality levels should be monitored at least every 6 hours (more frequently at first, but never less frequently) while hypertonic saline is administered.
Comment in South Med J. 1995 May;88(5):602. Guidelines for appropriate use of hypertonic (3%) saline (HS) for the treatment of hyponatremia are ill-defined. We reviewed each infusion of HS in a 400-bed university hospital over a 1-year period.
osmolarity < 320. 3. Hypertonic saline therapy guidelines and dosing a. Hypertonic saline should only be used in cases of. HHH as described above b. Plasma osmolarity or tonicity and serum sodium should be monitored every 12-24 hours i. Plasma osmolarity or tonicity should be calculated using the following formulae: 1.
Hypertonic. Hyponatraemia. Consider hyperglycaemia. (e.g. HHS), mannitol infusion. Urine Osm < 100 = Consider primary polydipsia. Check Urine Na+. Urine Na+ > 20. Likely SIADH. Follow guidance on page 4. Urine Na+ < 20. Reconsider hypo/hypervolaemia. If fluid status is unclear. Therapeutic trial of 0.9% saline (e.g.
27 Jun 2015 acts to cause water retention. On correction of hypovolaemia (e.g. with isotonic or hypertonic saline), this stimulus for vasopressin production decreases, and large volumes of dilute urine may result. Very rapid and potentially damaging rises in serum sodium concentration (e.g. >2 mmol/hr) may result.
3 Aug 2009 This literature review evaluates the use of hypertonic saline in critical care. The putative mechanism of action is presented, followed by a narrative review of its clinical usefulness in critical care. The review was conducted using the Scottish Intercollegiate Guidelines Network method for the review of cohort
6 Jan 2018 and Transplant Association have released guidelines on the diagnosis, classification, and treatment of true hypotonic hyponatremia. Treatment recommendations include the following : For serious symptomatic hyponatremia, the first line of treatment is prompt intravenous infusion of hypertonic saline,
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