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(sublines) may be inappropriate for genetic toxicology testing because of genetic instability; the WBL clone of CHO cells has given good results in several laboratories and appears to be stable [47]. Appropriate characteristics of cells should be determined as listed by OECD. TG473 before conducting GLP experiments.
Transgenic rodent (TGR) somatic and germ cell gene mutation assays, EU: B.58, OECD: 488 (2011, 2013). In vivo When there is a positive result from an in vitro cytogenicity study in mammalian cells (OECD 473) or from an in vitro . echa.europa.eu/documents/10162/13632/information_requirements_r7a_en.pdf.
473. Adopted: 21st July 1997. 1/10. OECD GUIDELINE FOR THE TESTING OF CHEMICALS. In Vitro Mammalian Chromosome Aberration Test. INTRODUCTION. 1. The purpose of the in vitro chromosome aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian cells (1)(2)(3)
29 Jul 2016 Test No. 473: In Vitro Mammalian Chromosomal Aberration Test You or your institution have access to this content. Replaces: Test No. 473: In Vitro Mammalian Chromosomal Aberration Test. English. Click to Access: oecd.metastore.ingenta.com/content/9716391e.pdf. PDF.
473: In Vitro Mammalian Chromosomal Aberration Test. In series:OECD Guidelines for the Testing of Chemicals, Section 4: Health Effectsview more titles. Published on July 29, 2016. Also available in: French. book. Read online · Download PDF · Get citation details. The purpose of the in vitro chromosome aberration test is
26 Sep 2014 The OECD Guidelines for the Testing of Chemicals are periodically reviewed in light of scientific progress, changing regulatory needs, and animal welfare considerations. The original Test Guideline 473 was adopted in 1983. In 1997 a revised version was issued, based on scientific progress made to that
471 Bacterial reverse mutation test (also named Ames test). 1983. 473 In vitro mammalian chromosomal aberration test. 1983. 474 Mammalian erythrocyte micronucleus test. 1983. 475 Mammalian bone marrow chromosomal aberration test. 1984. 476 In vitro mammalian cell gene mutation test. 1984 using the hprt or xprt
26 Sep 2014 detect aneuploidy-inducing agents that are difficult to study in conventional chromosomal aberration tests,. e.g. OECD Test Guideline 473 (18). However, the MNvit test as described in this Test Guideline does not allow for the differentiation of substances inducing changes in chromosome number and/or
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