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Most patients will be better served by first-line treatment with bismuth quadruple therapy or concomitant therapy consisting of a PPI, clarithromycin, amoxicillin, and metronidazole. When first-line therapy fails, a salvage regimen should avoid antibiotics that were previously used.
the previous guidelines published by the European. Helicobacter Study Group in Maastricht 2000 (see. Table 1). Dyspepsia. There is a need to define non-investigated and investigated dyspepsia and to consider them separately. Treatment of non-investigated dyspepsia may be different if the incidence of H. pylori is as low.

The main reason for failure of eradication is H. pyloriresistant strains. New treatment options include: extension of the length of proton pump inhibitor-based triple therapies, sequential therapy, quadruple therapy, levofloxacin-based triple or quadruple therapy.
1 Jun 2017 Helicobacter pylori (H. pylori) treatment remains a challenge for the clinician, as no available therapy is able to cure the infection in all treated patients. In the last two decades, several antibiotic combinations have been proposed, including triple therapies, bismuth-free therapies (sequential, concomitant,
9 Feb 2017 Levofloxacin-based sequential therapy is superior to clarithromycin- and tetracycline-based therapies and consists of the following (eradication rates of up to 92.2%, as long as the H pylori was susceptible to levofloxacin): PPI (esomeprazole 40 mg BID) + amoxicillin (1 g BID) for 7 days, then.
2 Jan 2018 Multiple antibiotic regimens have been evaluated for Helicobacter pylori therapy [1-5]. However, few regimens have consistently achieved high eradication rates. There are also limited data on H. pylori antibiotic resistance rates to guide therapy. The treatment regimen that is selected must consider local
22 Jul 2016 working group of specialists chosen by the Canadian Asso- ciation of Gastroenterology. RESULTS: Because of increasing failure of therapy, the consensus group strongly recommends that all H pylori eradication regimens now be given for 14 days. Recommended first-line strategies include concomitant.
Background. The eradication of Helicobacter pylori (H. pylori) can be challenging in certain circumstances. There is no current first-line therapy that is curative in all patients.
5 Feb 2016 Summary of NICE guidance on Helicobacter treatment.

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March 2018