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Principles and Applications of Gene Therapy in Colon Cancer. Rajaraman Durai1,2, Shi Yu Yang1, Alexander M Seifalian1,2, Marc C Winslet1,2. 1) Academic Division of Surgical and Interventional Sciences, University College London 2) Royal Free Hampstead NHS. Trust Hospital, London, United Kingdom. Abstract.
Gene therapy I: principles and clinical applications. J. Wesley Ulm. Harvard Medical School, Brookline, MA, USA. 1. Introduction. Gene therapy is a novel pharmacological approach in which the drug is supplied in the form of a nucleic acid – DNA, RNA, or some modification or combination thereof. The origin of gene therapy
22 May 1995 CONCLUSIONS: The clinical application of genetic modification techniques has thus far been successful in the beginning phases of this field. These early results suggest that continuation of gene therapy trials designed to correct the molecular changes that lead to disease states in humans is warranted.
Serv/LexUriServ.do?uri=OJ:L:2009:242:0003:0012:EN:PDF (accessed 07 August 2012). [5] Zhang Y, Satterlee A, Huang L. In Vivo Gene Delivery by Nonviral Vectors: Over? coming Hurdles?. Molecular Therapy 2012; 20(7) 1298-1304. [6] Gene Therapy Clinical Trials Worldwide.Provided by the Journal of Gene Medicine.
The concept of transferring genes to tissues for clinical applications has been discussed for nearly half a century, but our ability to manipulate genetic mater Download PDF PDF download for Gene Therapy: Some History, Applications, Problems, and Prospects, Article information
Gene Therapy Applications to Cancer Treatment. Susy M. Scholl,? Silke Michaelis, and Ray McDermott. Department of Medical Oncology, Institut Curie, 26 rue D'ulm 75248, Paris Cedex 05, France. Received 24 June 2002; accepted 19 July 2002. Over the past ten years significant advances have been made in the fields of
1 Jun 2009 Gene therapy is an emerging area of medicine, with Gene therapy applications. SUMMARY. Gene therapy has the potential to treat a variety of cancers, neurological disorders and infectious diseases, as well as cardiac .. clinical setting. www.hse.gov.uk/biosafety/gmo/acgm/acgmcomp/part6.pdf.
therapy, a disabled organ is better able to function normally. This technology has many applications to human health. One variant of somatic cell gene therapy is DNA vaccines, which allow cells of the immune system to fight certain diseases in a method similar to con- ventional vaccines. Stem cell therapy involves the use
Gene Transfer Technology in Therapy: Current Applications and Future Goals. GAETANO ROMANO,a CARMEN PACILIO,b ANTONIO GIORDANO b. aKimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania,. USA; bDepartment of Pathology, Anatomy and Cell Biology,
The number of gene therapy protocols for the treatment of cancer is growing rapidly. The most common type of approved clinical trial for cancer gene therapy involves the ex vivo gene transfer of cytokine genes (e.g., tumor ne- crosis factor, interleukin-2, granulocyte-macrophage col- ony-stimulating factor) into tumor cells.
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