or create an immunosuppressive microenvironment to prevent tumor eradication by host immune system, the so-called “cancer immunoediting" hypothesis. The aim of the present study was to find evidence for this hypothesis by using a
15 Oct 2003 Key Words immunosurveillance, tumor, lymphocytes, interferon, tumor sculpting s Abstract After a century of controversy, the notion that the immune system regu- lates cancer development is experiencing a new resurgence. An overwhelming amount of data from animal models—together with compelling
Annu Rev Immunol. 2004;22:329-60. The three Es of cancer immunoediting. Dunn GP(1), Old LJ, Schreiber RD. Author information: (1)Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. After a century of controversy, the notion that
17 Aug 2004 of Cancer Immunosurveillance and Immunoediting tective versus tumor-sculpting actions of the immune system in cancer (Shankaran et al., 2001; Dunn et al.,. 2002, 2004). Herein, we summarize recent work on the cancer immunosurveillance and immunoediting pro- cesses—underscoring a new optimism
Nat Immunol. 2002 Nov;3(11):991-8. Cancer immunoediting: from immunosurveillance to tumor escape. Dunn GP(1), Bruce AT, Ikeda H, Old LJ, Schreiber RD. Author information: (1)Department of Pathology and Immunology, Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue,
Interferons, immunity and cancer immunoediting. Gavin P. Dunn, Catherine M. Koebel and Robert D. Schreiber. Abstract | A clear picture of the dynamic relationship between the host immune system and cancer is emerging as the cells and molecules that participate in naturally occurring antitumour immune responses are
Cancer immunoediting from immune surveillance to immune escape. Introduction. Since Ehrlich in 1909 first proposed the idea that nascent transformed cells arise continuously in our bodies and that the immune system scans for and eradicates these transformed cells before they are manifested clinically, immune
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. Issue: The Renaissance of Cancer Immunotherapy. Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy. Matthew D. Vesely and Robert D. Schreiber. Department of Pathology and Immunology, Washington University School of

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February 2018