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21 Sep 2015 Aminoglycoside (AG) antibiotics are used to treat many Gram-negative and some Gram-positive infections and, importantly, multidrug-resistant tuberculosis. Among various bacterial species, resistance to AGs arises through a variety of intrinsic and acquired mechanisms. The bacterial cell wall serves as a
The aminoglycoside resistance mechanisms revealed by two surveys in Europe and other countries have been compared to those revealed in earlier studies. Mechanisms have become more complex in all bacterial groups. In Providencia, Serratia, Pseudomonas, Acinetobacter, and Staphylococcus species isolates
30 Apr 2010 Aminoglycoside resistance mechanisms in. Enterobacteriaceae. An experimental study based on human clinical isolates from western. Norway. Kine Risberg. University of Tromso. Faculty of Medicine. Department of Pharmacy. 2010
14 Jun 2017 1) in 1949 (120). Toxicity issues associated with neomycin and emerging streptomycin resistance spurred additional aminoglycoside discov- ery in the 1950s and early 1960s with the group of. Umezawa, in particular, in Japan reporting kanamycin. (114) and gentamicin by Weinstein at Schering (123). (Fig.
commonly found in aminoglycoside-resistant gram-negative strains. All three strains (and a transductant derived from one of them) contain two enzymes mediating gentamicin resistance, an aminoglvcoside 6'-N-acetyltransferase and a novel enzyme, gentamicin phosphotransferase. There have been a number of recent
Before considering resistance to aminoglycosides, it is necessary briefly to consider the structure and mode of action of these compounds. The aminoglycosides, most of which strictly speaking should be called aminoglycosidic aminocyclitols, may be divided into two main groups on the basis of whether they contain.
INTRODUCTION. Antimicrobial resistance has been recognized as one of the most pressing public health and societal issues of our times. The problem is most acute in gram-negative bacteria, where strains resistant to multiple (multidrug-resistant [MDR]) or almost all (extensively drug-resistant [XDR]) available agents are
For 10 years the 700-bed Minneapolis Veterans Affairs Medical Center has conducted a policy of carefully controlled aminoglycoside usage and monitoring of resistance of over 25,000 aerobic and facultative gram-negative bacillary isolates to the aminoglycosides. On two occasionsduring the 1980s, our experience of.
22 Dec 2017 On Jan 1, 2009, Maria L. Magalhaes (and others) published the chapter: Aminoglycosides: Mechanisms of Action and Resistance in the book: Antimicrobial Drug Resistance.
5.1.2 Aminoglycoside resistance in ESBLA-positive E. coli and Klebsiella spp. in Norway ______ 75 of aminoglycoside resistance among Gram-negative bacteria in Norway is low, but an increased prevalence among (www.abbiodisk.com/pdf/etm_html/03_etm.htm Access date: 18022011) (Figure 14). The MIC is
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