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1 Sep 2012 The American Academy of Neurology (AAN), the American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM), and the American Academy of Physical Medicine and Rehabilitation (AAPMR) have developed an evidence-based guideline for the treatment of painful diabetic neuropathy.
In patients with PDN, what is the efficacy of pharmacologic agents to reduce pain and improve physical function and quality of life (QOL)? If clinically appropriate, pregabalin should be offered for the treatment of PDN (Level A†). Gabapentin and sodium valproate should be considered for the treatment of PDN (Level B).
11 Apr 2011 Painful diabetic neuropathy (PDN) affects 16% of patients with diabetes, and it is frequently unreported (12.5%) and more frequently untreated (39%). This guideline addresses the efficacy of pharmacologic and nonpharmacologic treatments to reduce pain and improve physical function and QOL in patients with PDN.
Painful diabetic neuropathy (PDN) affects 16% of patients with diabetes, and it is frequently unreported (12.5%) and more frequently untreated (39%) [3]. PDN presents an ongoing management problem for patients, caregivers, and physicians. There are many treatment options available, and a rational approach to treating

The objective of this report was to develop a scientifically sound and clinically relevant evidence-based guideline for the treatment of painful diabetic neuropathy (PDN). The basic question that was asked was: 'What is the efficacy of a given treatment (pharmacological: anticonvulsants, antidepressants, opioids, others;
AANEM PRACTICE TOPIC. EVIDENCE-BASED GUIDELINE: TREATMENT OF PAINFUL DIABETIC. NEUROPATHY—REPORT OF THE AMERICAN ASSOCIATION OF. NEUROMUSCULAR AND ELECTRODIAGNOSTIC MEDICINE, THE. AMERICAN ACADEMY OF NEUROLOGY, AND THE AMERICAN ACADEMY.
11 Apr 2011 Evidence-based guideline: Treatment of painful diabetic neuropathy—report of the american association of neuromuscular and electrodiagnostic medicine, the american academy of neurology, and the american academy of physical medicine & rehabilitation
Venlafaxine, duloxetine, amitriptyline, gabapentin, valproate, opioids (morphine sulfate, tramadol, and oxycodone controlled-release), and capsaicin are probably effective and should be considered for treatment of PDN (Level B). Other treatments have less robust evidence or the evidence is negative.
The basic question asked was: “What is the efficacy of a given treatment (pharmacological: anticonvulsants, antidepressants, opioids, others; and non-pharmacological: electrical stimulation, magnetic field treatment, low-intensity laser treatment, Reiki massage, others) to reduce pain and improve physical function and

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January 2025