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A systematic analysis of the pharmacologic treatment of insomnia in patients over 60 years old found that, although sleep was better with sedatives than with placebo,.. 63% of patients were benzodiazepine free within 7 wk on average; 85% in combined treatment arm were benzodiazepine free after initial intervention v. A barbiturate is a drug that acts as a central nervous system depressant, and can therefore produce a wide spectrum of effects, from mild sedation to total anesthesia. They are also effective as anxiolytics, hypnotics, and anticonvulsants. Barbiturates have addiction potential, both physical and psychological. They have. Full-text (PDF) | Hypnotics are widely used by the elderly, and their impact on mortality remains controversial. The inconsistent findings could. French cities and free of dementia at baseline. Adjusted Cox proportional... the World Health Organization's Anatomical Therapeutic. Chemical Classification [34]. Benzodiazepines are known for their potential for abuse and that's precisely why alternatives to their various uses exist in medicine, ones this... Analyses were carried out on 6,696 participants aged 65 years or older randomly recruited from three French cities and free of dementia at baseline... use of antidepressants and hypnotics were coded according to the World Health Organization's Anatomical Therapeutic Chemical Classification [34]. Benzodiazepines currently account for 62% and Z drugs (zaleplon, zolpidem, and zopiclone) 32% of total prescriptions for hypnotics and anxiolytics in. into the Clinical Practice Research Datalink in 2012) was created in 1987 and is the largest anonymised, longitudinal primary care database in the world,. S. John Mihic; R. Adron Harris. The benzodiazepine sedative-hypnotics resemble such agents; although coma may occur at very high doses, neither surgical anesthesia nor fatal intoxication is produced by... 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