path.1706. Review Article. Molecular mechanisms of drug resistance. DB Longley* and PG Johnston. Drug Resistance Laboratory, Centre for Cancer Research and Cell Biology, Queen's University Belfast,
Molecular Mechanisms of Antibiotic Resistance: The Need for. Novel Antimicrobial Therapies. John W. Dale-Skinner and Boyan B. Bonev. Abstract. Despite the enormous success of antibiotics as chemotherapeutic agents, infectious diseases remain a leading cause of mortality worldwide. Bacteria coevolving with infectious
1 Dec 2014 Molecular mechanisms of antibiotic resistance. Jessica M. A. Blair, Mark A. Webber, Alison J. Baylay, David O. Ogbolu and. Laura J. V. Piddock. Abstract | Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly common and are causing a global health crisis. Antibiotic
9 May 2011 our current knowledge of the molecular mechanisms of drug resistance to the main classical and new anti-. TB drugs and briefly discusses some implications of the development of drug resistance and fitness, trans- mission and pathogenicity of M. tuberculosis. Keywords: TB, MDR, XDR, quinolones, fitness.
Infectious diseases caused by bacterial pathogens represent a serious public health concern. Antimicrobial agents such as anti-bacterial drugs are often indicated for chemotherapy of bacterial infections in clinical medicine. Thus, it is important to study the biological mechanisms that confer bacterial pathogenesis and
mechanisms work from the standpoint of molecular physiology and biochemistry will identify new targets for potential inhibition of multi-drug resistance and thus restore clinical utility of chemotherapy of infectious disease caused by serious bacterial pathogens. Keywords antimicrobial agent; drug; antibacterial drug; bacteria;
II. MOLECULAR GENETICS OF ANTIBIOTIC RESISTANCE. Bacteria are rapidly growing organisms. A typical infection that causes symptoms will contain 109 to. 1012 bacteria. Based on normal genetic variability, this population of bacteria will have a wide variability of response to an individual antibiotic. In the face of
36, 445-453. Molecular mechanisms of drug resistance in fungi. Hugo Vanden Bossche, Patrick Marichal and Frank C. Odds. T he frequency of life- threatening fungal in- fections is rising world- wide. This trend results from the increasing use of immuno- suppressive and cytotoxic drugs, and more powerful antibiotic agents
23 Mar 2007 Rather than providing an extensive list of antibiotic resistance mechanisms (which can be found elsewhere [Alekshun and Levy, 2000]), the aim of this Review is to highlight common genetic and molecular mechanisms of resistance as they relate to important pathogens and to drugs used by physicians

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March 2018