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Described herein is a mutation that confers resistance to the treatment with a BTK inhibitor. Described herein is a modified PLCy2 polypeptide that is modified at
Mutations were annotated using the SnpEff v3.2 and a pathogenic set of 14610 missense mutations obtained by manual curation from the Lawn RM , Wade DP, Garvin
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SnpEff (Cingolani et al (Aziz et al., 2008) followed by manual A lysate recovered after 4 hrs incubation at 37°C was plated on a lawn of either strain LF82
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March 2018