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S6k phosphorylation of irs1040ainstructions: >> http://sln.cloudz.pw/download?file=s6k+phosphorylation+of+irs1040ainstructions << (Download)
S6k phosphorylation of irs1040ainstructions: >> http://sln.cloudz.pw/read?file=s6k+phosphorylation+of+irs1040ainstructions << (Read Online)
The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Dennis PB(1), Pullen N, Kozma SC, Thomas G. Author information: (1)Friedrich Miescher-Institut, Basel, Switzerland. Mitogen-induced activation of p70(s6k) is associated
Furthermore, S302 is constitutively phosphorylated in TSC2 ? / ? MEFs, and this phosphorylation is inhibited by treatment with either rapamycin or S6K1 small interfering RNAs. The results from in vitro binding assays suggest that phosphorylation of this site by S6K hinders the ability of IRS-1 to associate with the insulin
Cancer Res. 2002 Oct 15;62(20):5689-97. Ultraviolet-induced phosphorylation of p70(S6K) at Thr(389) and Thr(421)/Ser(424) involves hydrogen peroxide and mammalian target of rapamycin but not Akt and atypical protein kinase C. Huang C(1), Li J, Ke Q, Leonard SS, Jiang BH, Zhong XS, Costa M, Castranova V, Shi X.
Jun 28, 2013 S6K (ribosomal S6 kinase p70, p70S6K) activation requires phosphorylation at two stages. The first phosphorylation is independent of insulin stimulation and mediated by an unknown kinase. The second phosphorylation is mediated by mTOR in insulin dependent manner. In this study, we identified JNK1
Moreover, in IKK2 (but not IKK1)-null cells, TNF-? treatment did not result in Thr-389 phosphorylation of S6K1. We present a new mechanism for TNF-? to induce insulin resistance that involves activation of S6K by an IKK2-dependent pathway. S6K directly phosphorylates IRS-1 on multiple serine residues to inhibit insulin
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