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open field test definition
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29 Jun 2005 -Secretase, or BACE1, is the rate limiting protease for the generation of the amyloid - peptide in Alzheimer's disease. Mice in which the BACE1 gene is inactivated are reported to be healthy. However, the presence of a homologous gene encoding BACE2 raises the possibility of compensatory mechanisms.
Originally introduced as a measure of emotional behaviour in rats, open field exploration. has proven to be equally successful with mice. The test provides a unique opportunity to. systematically assess novel environment exploration, general locomotor activity, and provide. an initial screen for anxiety-related behaviour in
9 Jul 2004 A central square (18 cm x 18 cm) was drawn in the middle of the open field (Brown, Corey,. & Moore, 1999). The central square is used because some mouse strains have high locomotor activity and cross the lines of the test chamber many times during a test session. Also, the central square has sufficient
OPEN-FIELD TEST. 4S3 and its surroundings; and (d) aU prior ei- perience of the tet situation. In e&'ect, tbis last factor means that one is measuring,. . to be asigni&ant effect for the test behavior of mice. However, Satinder (1969) found that the time spent by a rat on the side of the open field which had been occupied by.
29 Aug 2014 Results of the Open Field Test at different light intensities in C57 mice. F.J. Martin-Arenas1 and C.O. Pintado1. 1Centro de Produccion y Experimentacion Animal/CITIUS, University of Seville, Seville, Spain. animalario@us.es. Introduction. There is widespread agreement on the need for standardization of
We performed open-field tests on house mice (Mus domesticus) from four repli- cate lines genetically selected for high voluntary wheel-running for 22 generations and from four replicate random-bred control lines. Individual mice were recorded by video camera for 3 min in a 1-m2 open-field arena on 2 consecutive days.
Existing software solutions used to analyze overhead video recording of mice movement in an Open Field test rely on traditional computer vision-based image analysis. While quite successful in providing basic behavioral metrics, face significant difficulties in analyzing more complex patterns. In addition, they require
7 Aug 2011 The Open Field Test for Mice. 1.0. PURPOSE. This procedure describes how to acclimate and test mice in the open field test. This is a commonly used paradigm to test locomotion, anxiety-like behavior, exploratory behavior, and activity levels. 2.0 SCOPE (Should include which Cores this SOP applies to).
6 Feb 2015 For this analysis, use the SMART Video Tracking software from PanLab/Harvard Apparatus to record and evaluate mouse movement. NOTE: Any commercial video tracking camera and software may be used to track the test subject and evaluate results from the open field maze. It is very important for the
31 Dec 2014 given access to normal mice chow and water ad libitum. The Open field apparatus and the light/dark box were used to measure locomotor/exploratory behaviour and anxiety. Results: There was a significant (p=0.05) reduction in the frequencies of rearing, walling and line crossing in the Open field test and
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