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25 Sep 2017 STAMPEDE: Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy: A Multi-Stage Multi-Arm Randomised Controlled Trial (STAMPEDE)
20 Sep 2012 Appraising multiple-armed RCTs. The most familiar RCT design for many of us is the standard two-armed, parallel-design, individually randomised trial. The two arms in this case generally include the treatment arm and the control arm (alternative treatment/placebo arm). However, other RCT designs also
Correcting for multiple-testing in multi-arm trials: is it necessary and is it done? James M S Wason†Email author,; Lynne Stecher† and; Adrian P Mander. †Contributed equally. Trials201415:364. https://doi.org/10.1186/1745-6215-15-364. © Wason et al.; licensee BioMed Central Ltd. 2014. Received: 25 April 2014.
27 Mar 2017 The method is applied, for illustrative purposes, to a multi-arm clinical trial of chronic obstructive pulmonary disease in Section 'The INHANCE Clinical Trial of .. We show in Appendix S1 of the Supplementary Materials that the probability equations (2.3) and (2.6) can be solved by repeated evaluation of
17 Apr 2009 Methods. In this paper, we evaluate the performance of the two-stage, multi-arm design using four cancer trials conducted at the MRC CTU. The performance of the design at fictitious interim analyses is assessed using a conditional bootstrap approach.
22 Apr 2015 Keywords: Adding a treatment arm, Flexible design, Multi-arm multi-stage, MAMS, Adaptive design, Type I error, Family-wise error rate, Statistical The ProQuest database was also searched to identify further relevant grey (unpublished) material such as dissertations and theses, and conference papers.
Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trial. Matthew R SydesEmail author,; Mahesh KB Parmar,; Nicholas D James,; Noel W Clarke,; David P Dearnaley,; Malcolm D Mason,; Rachel C Morgan,; Karen Sanders and; Patrick Royston. Trials200910:39.
14 Sep 2017 Package 'MAMS'. September 14, 2017. Type Package. Title Designing Multi-Arm Multi-Stage Studies. Version 1.2. Author Thomas Jaki <jaki.thomas@gmail.com>, Dominic Ma- girr <d.magirr@gmail.com>, Philip Pallmann
. Maintainer Thomas Jaki <jaki.thomas@gmail.com>.
East MULTIARM guides users through the complexities of multiplicity adjustment in order to construct reliable trials with multiple arms. A crucial regulatory of optimal trial design. The merits of each design are easy to communicate to the study team by using East MULTIARM's powerful simulations and intuitive visuals.
12 Dec 2012 Multi-arm multi-stage designs can improve the efficiency of the drug-development process by evaluating multiple experimental arms against a common control within one trial. This reduces the number of patients required compared to a series of trials testing each experimental arm separately against control
East MULTIARM guides users through the complexities of multiplicity adjustment in order to construct reliable trials with multiple arms. A crucial regulatory of optimal trial design. The merits of each design are easy to communicate to the study team by using East MULTIARM's powerful simulations and intuitive visuals.
12 Dec 2012 Multi-arm multi-stage designs can improve the efficiency of the drug-development process by evaluating multiple experimental arms against a common control within one trial. This reduces the number of patients required compared to a series of trials testing each experimental arm separately against control
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