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5 Dec 2015 Treatment of hemophagocytic lymphohistiocytosis (HLH) has been developed primarily in pediatric centers, where familial HLH (FHL) is the leading cause of HLH in newborns and toddlers. The Histiocyte Society Study Group for HLH developed the HLH-94 and HLH-2004 treatment protocols, and these
prospective international treatment protocol (HLH-94) was introduced [8]. The cumulative experiences from HLH-94 and other studies have led to the development of a new treatment protocol presented here, HLH-2004, which includes updated diagnostic and therapeutic guidelines from the Histiocyte Society. DIAGNOSIS
helpful to think of HLH as the severe end of the spectrum of hyperinflammatory disorders when the immune system starts to damage host tissues . organized therapeutic protocol, HLH-94, resulted in an overall survival rate of 55%, with a Histiocyte Society (HS) trials HLH-94 and HLH-2004 (Table 2);. 5 of 8 criteria are
Pediatr Blood Cancer. 2007 Feb;48(2):124-31. HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Henter JI(1), Horne A, Arico M, Egeler RM, Filipovich AH, Imashuku S, Ladisch S, McClain K, Webb D, Winiarski J, Janka G. Author information: (1)Childhood Cancer Research Unit,
3 Feb 2012 HLH-2004 protocol and allogeneic haematopoietic stem- cell transplantation (allo-HSCT) [7, 8], are most culturing of blood, bone marrow or. Swiss Medical Weekly · PDF of the online version · www.smw.ch HLH-2004 treatment protocol, IVIG and other clinical tri- als. Subsequent therapy. The aim of
1 May 2017 Clinicopathologic diagnosis of: Hemophagocytic Lymphohistiocytosis (HLH) associated with a malignant lymphoproliferative disorder for six months afterwards. BC Cancer Agency Protocol Summary HLHETCSPA . Table 1: Diagnostic criteria for HLH used in the HLH-2004 trial2. A. Molecular diagnosis
9 Aug 2011 revised for the HLH-2004 trial and serves as a current de facto definition of HLH. These criteria .. first international treatment protocol for HLH was organized by the Histiocyte Society in 1994 and led to The Histiocyte Society opened a new trial in 2004, HLH-2004, which is currently enrolling patients.
Estimated Enrollment : 300 participants. Intervention Model: Single Group Assignment. Masking: None (Open Label). Primary Purpose: Treatment. Official Title: HLH-2004 Treatment Protocol. Study Start Date : January 2004. Primary Completion Date : December 2011. Estimated Study Completion Date : December 2017
CONTENTS. ADDRESSES Study committee, Local coordinators, Study data manager. 3. Data safety monitoring board, Senior advisors. 4. FIGURE 1 Flow sheet for children with HLH in HLH-2004. 5. FIGURE 2 Treatment protocol overview for HLH-2004. 6. FIGURE 3 Documentation sheet for the initial therapy in HLH-2004.
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