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Int. J. Adv. Multidiscip. Res. (2016). 3(9): 41-51. 42. Structure-based classification of the NSAIDs: Based on their structures, they are classified as follows:(4,5). A. Non-selective COX inhibitors (i.e. traditional NSAIDs):. Sl. No. Class. Example. Structure. 1. Salicylate derivative. Aspirin. 2. Pyrazolone derivative. Phenylbutazone.
CLASSIFICATION OF NSAIDs. ? Nonselective COX inhibitors(COX1&2). (conventional). 1.SALICYLATES:Aspirin. 2.PARA AMINOPHENOL DERIVATIVES: Paracetamol (acetaminophen), phenacetin. 3.PYRAZOLONE DERIVATIVES: Phenylbutazone, oxyphenbutazone, metimazole,propiphenazone. 4.ACETIC ACID
Figure 1. Chemical Classification of the NSAIDs colleagues had discovered the inhibitory actions of aspirin and related drugs on the production of prostaglandins). Their anti-inflammatory, analgesic and anti- pyretic properties were discovered using animal models with some supportive properties being established in some
CLASSIFICATION OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs). 1) Carboxylic Acids a) Salicylic Acids & Esters. ASA1. Diflunisal b) Acetic Acids i) Phenylacetic Acids. Diclofenac1 ii) Carbo- and Hetero-Cyclic Acetic Acids. Indomethacin1. Ketorolac2. Sulindac. Tolmetin c) Propionic Acids. Flurbiprofen.
ANTI-INFLAMMATORY EFFECTS OF NSAIDs. This effect of NSAIDs is due to the inhibition of the enzyme COX, which converts arachidonic acid to prostaglandins, TXA2 and prostacyclin. Acetylsalicylic acid irreversibly inactivates COX-1 and COX-2 by acetylation of a specific serine resideu. Other NSAIDs reversibly inhibit
Chemical Classes of. Non-Steroidal Anti-Infammatories (NSAIDs) in US. Carboxylic Acids. Acetic Acids. Enoloic Acids. Oxicams. Phenylacetic Acids. Diclofenac (Volaren®,. Cataflam®, Flector ®). Carbo- and Heterocyclic. Acids. Etodolac (Lodine®). Indomethacin (Indocin®). Ketorolac (Toradol®). Sulindac (Clinoril®).
Classification of NSAIDs. • Salicylates: aspirin, Sodium salicylate & diflunisal. • Propionic acid derivatives: ibuprofen, ketoprofen, naproxen. • Aryl acetic acid derivatives: diclofenac, ketorolac. • Indole derivatives: indomethacin, sulindac. • Alkanones: Nabumetone. • Oxicams: piroxicam, tenoxicam
carboxylic acids (see drug classes). Thus, salts forms can be generated upon treatment with base and all of these compounds are extensively ionized at physiologic pH. The acidic group is essential for COX inhibitory activity! • The NSAIDs differ in their lipophilicities based on the lipophilic character of their aryl groups and
REVIEW. A classification of NSAIDs according to the relative inhibition of cyclooxygenase isoenzymes. J. C. Frdich. Non-steroidal anti-inflammatory drugs (NSAIDs) are, as a group, the most frequently consumed drugs worldwide. They also cause the most, and often dangerous, side-effects repot-ted to the US Food and.
CLASSIFICATION OF NSAiDS. ANOTHER CLASSIFICATION OF NSAiDS. •. COX-1 inhibition, in general, is instantaneous and competitively reversible. •. COX-2 inhibition is time dependent, i.e. its effect increases with time. •. The COX-2-selective drugs have minimal gastrointestinal toxicity. •. COX-2 inhibitors no impact on

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March 2018