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Nature Genetics publishes the very highest quality research in genetics. variant in TM6SF2 influencing total cholesterol and myocardial infarction risk - pp 345
Jonathan Cohen, Helen Hobbs and colleagues show that adiposity significantly amplifies the effects of PNPLA3, TM6SF2, and GCKR sequence variants on
Cristen Willer, Kristian Hveem and colleagues use an exome array to identify a coding variant in TM6SF2 that is associated with total cholesterol levels.
We identified variants in the MBOAT7 (P = 1.03 ? 10?9) and TM6SF2 (P = 7.89 .. This first genome-wide genetic assessment for alcohol-related cirrhosis . to Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV)
We identified variants in the MBOAT7 (P = 1.03 ? 10?9) and TM6SF2 (P . Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in
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26 Jun 2014 Two recent studies identified TM6SF2 as a regulator of liver triglyceride content (Nat. Genet. 46, 352–356, 2014) and plasma total cholesterol
18 Nov 2014 The TM6SF2 Variants, Novel Genetic Predictors for Nonalcoholic . to the subjective nature of steatosis grade on liver biopsy examination
They further show that knockdown of Tm6sf2 in mice results in increased liver triglyceride content and reduced very-low-density Nature Genetics | Letter.
Scope, Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human traits and on

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March 2018