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27 Oct 2009 UPDATE ATUALIZACAO. A cell-based model of coagulation and its implications. Claudia Natalia FerreiraI; Marinez de Oliveira SousaII; Luci Maria Sant'Ana DusseII; Maria das Gracas CarvalhoII. IFundacao Hospitalar do Estado de Minas Gerais, Maternidade Odete Valadares, and City Office of Belo
updated over the last few decades, is flawed as a description of how hemostasis occurs in vivo. The recently proposed model incorporates the vital role of cells in coagulation processes, and corrects deficiencies of the older cascade models. Conclusions – The cell-based model of coagulation provides a description of
30 Apr 2015 For centuries homeostasis have been explained on the basis of the coagulation cascade where two separate pathways converge on a common pathway leading to the formation of thrombin. Thrombin in turn converts fibrinogen to fibrin. Monitoring of homeostasis is done based on this cascade model but
21 Dec 2017 Full-text (PDF) | Based on our work and that of many other workers, we have developed a model of coagulation in vivo. Many workers have demonstrated mechanisms by which cells can influence the coagulation process. Nonetheless, the prevailing view of hemostasis remains that the protein coagulation
Charter member and first Executive Director of. ISTH [Roberts Medal]. • First plasma-derived FVIII concentrate (glycine precipitation). • First description of a FIX molecular mutation. • Cell-based model of coagulation. • Recipient of: • French International Prize for Research in. Hemophilia,. • Kenneth Brinkhous Award (National.
We propose that coagulation occurs not as a "cascade", but in three overlapping stages: 1) initiation, which occurs on a tissue factor bearing cell; 2) amplification, in which platelets and cofactors are activated to set the stage for large scale thrombin generation; and 3) propagation, in which large amounts of
Cell based model of haemostasis. Anand Bhaskar, Associate Professor, Department of Physiology, Sukesh C. Nair, Professor, Department of. Transfusion Medicine and Immunohematology, Tony Abraham Thomas, Christian Medical College, Vellore. Summary: The complex process of coagulation that leads to hemostasis
contrast this with newer cellular models of how coagulation works in the body. we will also highlight some defects/ things that can go wrong in hemostasis. .. TF-Bearing Cell. IXa. TF. TF. TF. Hoffman M, Monroe DM: A Cell-Based Model of Hemostasis. Thromb Haemostas, 85:958-65, 2001. Initiation. Tissue factor bearing
Abstract Our cell-based model of haemostasis replaces the traditional 'cascade' hypothesis, and proposes that coagulation takes place on different cell surfaces in three overlapping steps: initiation, amplification, and propagation.
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