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27 Aug 2009 The gut microbiome encodes metabolic capacities that remain largely unexplored but include the degradation of otherwise indigestible components of our community harvested from conventionally raised mice produces a dramatic increase in body fat within 10–14 days, despite an associated decrease in
22 Apr 2015 Peter J. Turnbaugh, Ruth E. Ley, Michael A. Mahowald, Vincent Magrini, Elaine R. Mardis, Jeffrey I. Gordon. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031 (21 December 2006) | doi:10.1038/nature05414; Received 8 October 2006; Accepted 7
21 Dec 2006 Here we demonstrate through metagenomic and biochemical analyses that these changes affect the metabolic potential of the mouse gut microbiota. Our results indicate that the obese microbiome has an increased capacity to harvest energy from the diet. Furthermore, this trait is transmissible: colonization
21 Dec 2006 Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. This study implicates the nature of the gut microbiome as a determinant of the pathophysiology of obesity, and perhaps other conditions. 1 A core gut microbiome in obese and lean twins.
Their 2006 follow-up study used a combination of genetic sequence and biochemical analyses to further characterize this obesity-associated microbiome. Figure 2: Biochemical analysis and microbiota transplantation experiments confirm that theob/ob microbiome has an increased capacity for dietary energy harvest.[3].
27 Aug 2015 Article. Nature 444, 1027-1031 (21 December 2006) | doi:10.1038/nature05414; Received 8 October 2006; Accepted 7 November. 2006. An obesity-associated gut microbiome with increased capacity for energy harvest. Peter J. Turnbaugh1, Ruth E. Ley1, Michael A. Mahowald1, Vincent Magrini2, Elaine R
Nature. 2006 Dec 21;444(7122):1027-31. An obesity-associated gut microbiome with increased capacity for energy harvest. Turnbaugh PJ(1), Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. Author information: (1)Center for Genome Sciences, Washington University, St. Louis, Missouri 63108, USA. Comment in
Ley et al. [73], hs, Microbiota associated with obesity/weight loss, ^Firmicutes: Bacteroidetes, Increased energy harvest, small sample size (n<15/group). Turnbaugh et al. [123], mm, Increased adiposity, ^Firmicutes: Bacteroidetes, Increased energy harvest, Leptin's newly recognized role in gut immunity. Fleissner et al.
Voluntary Running Exercise Alters Microbiota Composition and Increases n-Butyrate Concentration in the Rat Cecum. Matsumoto Megumi , Inoue Ryo , Tsukahara Takamitsu , USHIDA Kazunari , CHIJI Hideyuki , MATSUBARA Noritaka , HARA Hiroshi. Bioscience, biotechnology, and biochemistry 72(2), 572-576, 2008-02-
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