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Daratumumab study guide: >> http://lhl.cloudz.pw/download?file=daratumumab+study+guide << (Download)
Daratumumab study guide: >> http://lhl.cloudz.pw/read?file=daratumumab+study+guide << (Read Online)
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21 Apr 2017 Overall, 569 patients with relapsed or refractory multiple myeloma enrolled in the open-label POLLUX study that compared the efficacy and safety of DRd with that of Rd.10,12 Daratumumab (16 mg/kg intravenously) was administered with preinfusion and postinfusion medications until unacceptable toxicity
Darzalex™ (daratumumab, Janssen/Genmab) is given as an intravenous (IV) infusion into a vein. It is typically given at a dose of 16 mg/kg of body weight and is administered weekly during Weeks 1 through 8, every two weeks during Weeks 9 through 24, and then every 4 weeks until disease progression. Before receiving
1 Dec 2016 This Clinical Guidance Report was prepared to assist the pCODR Expert Review Committee (pERC) in making recommendations to guide funding decisions made by the provincial and territorial. Ministries of Health and provincial cancer agencies regarding daratumumab (Darzalex) for multiple myeloma.
The safety and efficacy of Darzalex™ (daratumumab, Janssen/Genmab) was demonstrated in two Phase 1/2 clinical trials in heavily-pretreated relapsed and/or refractory myeloma. The SIRIUS study included 106 patients who had received at least 3 prior therapies, including a proteasome inhibitor and an IMiD, or who were
11 Sep 2017 Abstract. Background. D, a human CD38 IgG? mAb, induces deep, durable responses in pts with relapsed/refractory MM, as monotherapy and combined with other regimens. Infusion-related reactions (IRRs) occur in ?50% of D-treated pts, are generally mild to moderate, and usually occur during the 1st
30 May 2015 ASCO Annual MeetingMay 30, 2015According to a recent small study, the drug daratumumab may work well as a treatment for multiple myeloma after other Researchers found that after about nine months, daratumumab slowed the cancer's growth for 29% of patients. Guide to Multiple Myeloma.
13 Feb 2017 [4] At the same time, efficacy analyses of the 8 mg/kg dose in the phase II SIRIUS study demonstrated a low overall response rate (ORR).[4] In contrast, daratumumab 16 mg/kg demonstrated deep and durable responses while maintaining a favorable safety profile; therefore, daratumumab 16 mg/kg once
5 Jun 2016 ASCO Perspective. “Here, we've seen what can happen for patients when we select the treatment based on a common target in multiple myeloma. The new treatment regimen appears to rapidly slow cancer growth in many patients. This study affirms the efficacy of daratumamab that was seen in earlier,
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6 Jun 2016 A three-drug regimen that includes daratumumab doubled response rates and markedly reduced risk for progression, compared with standard therapy. This hazard ratio of 0.39 is "unprecedented in randomized studies that compare novel treatments in refractory multiple myeloma," said lead study author
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