. Throughout “Stem Cell Basics," many technical terms appear in bold, underlined maroon type. Click the term to see its definition in the Glossary at the end of the primer. I. Introduction: What are stem cells, and why are they important?
This document arises from the contributions of specialists in various areas of stem cell research, biomedical application and patient advocacy, who – in addition to writing the articles herein. – were invited to a consultative meeting held under the auspices of EMBO on 19 April 2006. This summary document provides an
Do you need to get one from an egg? Must you sacrifice an Embryo? What is an ES cell? What about adult stem cells or cord blood stem cells. Why can't this work be done in animals? Are “cures" on the horizon? Will this lead to human cloning – human spare parts factories? Are we going to make a Frankenstein?
Stem cells are unspecialized cells that develop into the specialized cells that make up the different types of tissue in the human body.They are characterized by the ability to renew themselves through mitotic cell division and differentiating into a diverse range of specialized cell types. They are vital to the development,
Totipotent. • post-fertilization to morula. • all the cells of the human body. Pluripotent. • inner cell mass of the blastocyst. • cells of all three germ layers. Multipotent. • hematopoietic stem cells neural stem cells mesenchymal stem cells. • various specialized cells in a given tissue. Adapted from
found in adult tissue. • can self-renew many times. • are multipotent –can differentiate to become only the types of cells in the tissue they come from. • hematopoietic stem cells – give rise to blood cells. • mesenchymal stem cells – give rise to cells of connective tissues and bones. • umbilical cord stem cells – a rich source.
Human pluripotent stem cells (hPSCs), represent- ed by embryonic stem (ES) and induced pluripotent stem (iPS) cells, possess a great potential for appli- cation in cell therapy and drug discovery. With their ability to produce an unlimited number of many kinds of human cells, hPSCs help overcome the chal- lenge of
understanding of the basic biology of the human body. By drawing on expert scientists, doctors, bioethicists, and others, the National. Academies have examined the potential of stem cell technologies for medicine and provided a forum for discussing the ethical implications and moral dilemmas of stem cell research. 2
STEM CELL AND. TISSUE ENGINEERING. World Scientific edited by. Song Li. University of California, Berkeley, USA. Nicolas L'Heureux. Cytograft Tissue Engineering, USA. Jennifer Elisseeff. Johns Hopkins University, USA. NEW JERSEY •. LONDON •. SINGAPORE •. BEIJING •. SHANGHAI •. HONG KONG •. TAIPEI •.
ES cells were first derived in 1981 from a MOUSE embryo. – Nature 292:54-156 (1981); Proc Natl Acad Sci USA 78:7634–7638 (1981). • Isolation of human ES cells by James Thomson, et al. in 1998. – Science 282:1145–1147 (1998). • Protocols for hES cell culture were optimized from mouse ES cells and other embryonic

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February 2018