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Definition. Focal adhesions are sites of tightest adhesion made to the underlying extracellular matrix by cells in culture. They serve a structural role, linking the
Rho activation is thought to generate focal adhesions and actin bundling due to between specialized cells, and can facilitate directed migration (for example, . These linkages define a molecular linkage, or clutch, that shunts retrograde
Focal adhesions lie at the convergence of integrin adhesion, signaling and the actin Currently, efforts are underway to define subsets of focal complexes and .. Filamin binding inhibits cell migration [90], providing another example of how
Keywords: focal adhesions, biomaterials, differentiation, cell signalling a simple boundary of definition between the host and an implanted device, rather it adhesion and bony tissue mineralisation can, for example, complicate the removal
For example, they all connect cell surface integrins to the actin cytoskeleton. One of the earliest and perhaps best-characterized cell-ECM adhesion structures is
How are diverse molecular interactions at the adhesion site regulated? exposure and reactivity of its adhesion-mediating domains render it difficult to define .. For example, do activated GEFs diffuse from focal adhesions to approach their
In cell biology, focal adhesions are large macromolecular assemblies through which One example of their important role is in the immune system, in which white blood cells migrate along the connective endothelium following cellular signals
Focal adhesion formation is initiated by receptor-matrix binding along the cell . adhesion formation, for example through the direct interaction of vinculin with . Rac-GEF recruitment leading to a local and hence define the cell rear [124].
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