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Title: Microfluidic resonant waveguide grating biosensor system for whole cell sensing. Authors: Zaytseva, Natalya; Miller, William; Goral, Vasily; Hepburn, Jerry; Fang, Ye. Affiliation: AA(Biochemical Technologies, Science and Technology Division, Corning Inc., Corning, New York 14831, USA), AB(Biochemical
Label-free optical biosensing with high sensitivity, throughput, compactness, and low cost, plays an important role to resolve these diagnostic challenges and pushes the detection limit down to single molecule. Optical nanostructures, specifically the resonant waveguide grating (RWG) and nano-ribbon cavity based
Abstract: This article presents theoretical analysis and experimental data for the use of resonant waveguide grating (RWG) biosensors to characterize
20 Nov 2010 Areas covered in this review: This article reviews why resonant waveguide grating (RWG) biosensor cellular assays are considered to be integrative in nature, and how RWG biosensor can be used for mining the surface markers of cancer cells and discovering core pathway(s) of cancer receptor signaling.
31 Jul 2013 Two label-free biosensor platforms, Resonance Waveguide Grating (RWG) and Surface Plasmon Resonance (SPR), were used to rank a large panel of anti-dengue virus NS1 antibodies. Dengue non-structural 1 (NS1) protein is an established serological marker for the early detection of dengue infection.
We report on a fluidic resonant waveguide grating (RWG) biosensor system that enables medium throughput measurements of cellular responses under microfluidics in a 32-well format. Dynamic mass redistribution assays under microfluidics differentiate the cross-desensitization process between the ?2 ? 2 -adrenoceptor
Bragg Gratings, Photosensitivity, and Poling in Glass Waveguides 2012. Colorado Springs, Colorado United States; 17–20 June 2012; ISBN: 978-1-55752-946-6. From the session. Sensor Symposium II (BTu4E). Resonant Waveguide Grating Biosensors for Cell Biology and Drug Discovery. Ye Fang. Author Information
19 Dec 2017 Full-text (PDF) | Label-free optical biosensors have been long used for biomolecular interaction analysis. Here I review recent advances of resonant waveguide grating biosensor systems for whole cell sensing, and their applications in cell biology and drug discovery.
These biosensors including surface plasmon resonance (SPR) and resonant waveguide grating (RGW) are mainly used to determine the affinities and kinetics of target analytes in a sample binding to the biological receptors immobilized on the sensor surface.
A RWG biosensor utilizes the resonant coupling of light into a waveguide by means of a diffraction grating. A polarized light, covering a range of incident wavelengths, is used to illuminate the waveguide; light at specific wavelengths is coupled into and propagate along the waveguide (Fig. 4).
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