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Biotransformation of xenobiotics pdf: >> http://nsm.cloudz.pw/download?file=biotransformation+of+xenobiotics+pdf << (Download)
Biotransformation of xenobiotics pdf: >> http://nsm.cloudz.pw/read?file=biotransformation+of+xenobiotics+pdf << (Read Online)
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Metabolism of xenobiotics. Also called: Biotransformation, or detoxification. Primary metabolism – secondary metabolism. Goal: To make use of a compound or to facilitate its excretion. Increases the water solubility of a compound. Divided in two phases, phase I and phase II
GENERAL PRINCIPLES. Basic Properties of Xenobiotic Biotransforming. Enzymes. Biotransformation versus Metabolism. Stereochemical Aspects of Xenobiotic. Biotransformation. Phase I and Phase II Biotransformation. Nomenclature of Xenobiotic Biotransforming. Enzymes. Distribution of Xenobiotic Biotransforming
Oct 9, 2017 On Dec 15, 2009, John A. Timbrell (and others) published the chapter: Biotransformation of Xenobiotics in the book: General, Applied and Systems Toxicology.
Biotransformation is the metabolic conversion of endogenous and xenobiotic chemicals to more water-soluble compounds. Xenobiotic biotransformation is accomplished by a limited number of enzymes with broad substrate specificities. Phase I reactions View Table|Favorite Table|Download (.pdf). Table 6–1 General
2. 1. Xenobiotic Metabolism: Definition. Xenobiotic = "foreign". Synonyms: Biotransformation; Drug Metabolism. Not: Detoxication Reactions. 2. Phase I and Phase II Reactions: Classification. Phase I Reactions: Oxidation, Reduction, Hydrolysis. Introduce one of following groups into the initial compound: -OH, -COOH, -NH2,
Biotransformation of Xenobiotics. Biological basis for xenobiotic metabolism: ? To convert lipid-soluble, non-polar, non- excretable forms of chemicals to water- soluble, polar forms that are excretable in bile and urine. Continued
Biotransformation of Xenobiotics. • Biotransformation VS. Bioactivation. • Changes that enhance excretion. • chemically distinct metabolite. • hydrophilicity. • membrane permeability. • reabsorption. • Effects on biological half life t 1/2. Biotransforming Enzymes. • Specificities? • Distribution. – organs:
Be able to describe fi i i f bi i d l d. Be able to describe. • Definitions of xenobiotics and related terms. • Fate of xenobiotics in the body. • Absorption of xenobiotics. • Distribution of xenobiotics. • Biotransformation (Metabolism) of xenobiotics. • Biotransformation (Metabolism) of xenobiotics. • Excretion of xenobiotics
Metabolic Transformations of Xenobiotics. (Introduction of Biotransformation reactions). Amin M. Kamel, Ph.D. Pfizer Global Research and Development. Groton Laboratories. Bioanalytical Course. University of Connecticut. April 10th , 2007. Chemistry Building T309. 11:00-12:15
Xenobiotic Biotransformation. ?????????????????????????????????????????????????. ???????. SCID 141. 2014-2015. Assoc. Prof. Dr. Krongtong Yoovathaworn and Dr. Porntipa Korprasertthaworn. Department of Pharmacology. Faculty of Science, Mahidol University
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